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How do short-term changes at synapses fine-tune information processing?

J Neurosci 32:14058-63. doi: 10.1523/JNEUROSCI.3348-12.2012

Authors/Editors: Klug A
Borst JG
Carlson BA
Kopp-Scheinpflug C
Klyachko VA
Xu-Friedman MA
Publication Date: 2012
Type of Publication: Journal Articles 2001 - 2018


Synaptic transmission is highly dependent on recent activity and can lead to depression or facilitation of synaptic strength. This phenomenon is called "short-term synaptic plasticity" and is shown at all synapses. While much work has been done to understand the mechanisms of short-term changes in the state of synapses, short-term plasticity is often thought of as a mechanistic consequence of the design of a synapse. This review will attempt to go beyond this view and discuss how, on one hand, complex neuronal activity affects the short-term state of synapses, but also how these dynamic changes in synaptic strength affect information processing in return.

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