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Adaptation in sound localization: from GABAB receptor-mediated synaptic

Nat Neurosci 16: 1840-7. doi: 10.1038/nn.3548

Authors/Editors: Stange A
Myoga MH
Lingner A
Ford MC
Alexandrowa O
Felmy F
Pecka M
Siveke I
Grothe B
Publication Date: 2013
Type of Publication: Journal Articles 2001 - 2017

Abstract

Across all sensory modalities, the effect of context-dependent neural adaptation can be observed at every level, from receptors to perception. Nonetheless, it has long been assumed that the processing of interaural time differences, which is the primary cue for sound localization, is nonadaptive, as its outputs are mapped directly onto a hard-wired representation of space. Here we present evidence derived from in vitro and in vivo experiments in gerbils indicating that the coincidence-detector neurons in the medial superior olive modulate their sensitivity to interaural time differences through a rapid, GABAB receptor–mediated feedback mechanism. We show that this mechanism provides a gain control in the form of output normalization, which influences the neuronal population code of auditory space. Furthermore, psychophysical tests showed that the paradigm used to evoke neuronal GABAB receptor–mediated adaptation causes the perceptual shift in sound localization in humans that was expected on the basis of our physiological results in gerbils.

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