Breadcrumb Navigation


Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence

Nat Neurosci 17: 1658-60. doi: 10.1038/nn.3843. Epub 2014 Oct 19.

Authors/Editors: McNamara CG
Tejero-Cantero A
Trouche S
Campo-Urriza N
Dupret D
Publication Date: 2014
Type of Publication: Journal Articles 2010 - 2019


We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence.

Related Links