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Effects of Locomotion Extend throughout the Mouse Early Visual System

Curr Biol 24: 2899-2907. doi: 10.1016/j.cub.2014.10.045. Epub 2014 Dec 4.

Authors/Editors: Erisken S
Vaiceliunaite A
Jurjut O
Fiorini M
Katzner S
Busse L
Publication Date: 2014
Type of Publication: Journal Articles 2001 - 2017

Abstract

BACKGROUND:

Neural responses in visual cortex depend not only on sensory input but also on behavioral context. One such context is locomotion, which modulates single-neuron activity in primary visual cortex (V1). How locomotion affects neuronal populations across cortical layers and in precortical structures is not well understood.

RESULTS:

We performed extracellular multielectrode recordings in the visual system of mice during locomotion and stationary periods. We found that locomotion influenced activity of V1 neurons with a characteristic laminar profile and shaped the population response by reducing pairwise correlations. Although the reduction of pairwise correlations was restricted to cortex, locomotion slightly but consistently increased firing rates and controlled tuning selectivity already in the dorsolateral geniculate nucleus (dLGN) of the thalamus. At the level of the eye, increases in locomotion speed were associated with pupil dilation.

CONCLUSIONS:

These findings document further, nonmultiplicative effects of locomotion, reaching earlier processing stages than cortex.

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