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Decreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorder

Hear Res. 330: 213-20. doi: 10.1016/j.heares.2015.06.014. Epub 2015 Jun 25. Review.

Authors/Editors: Kopp-Scheinpflug C
Tempel BL
Publication Date: 2015
Type of Publication: Journal Articles 2010 - 2019


The sense of hearing is the fastest of our senses and provides the first all-or-none action potential in the auditory nerve in less than four milliseconds. Short stimulus evoked latencies and their minimal variability are hallmarks of auditory processing from spiral ganglia to cortex. Here, we review how even small changes in first spike latencies (FSL) and their variability (jitter) impact auditory temporal processing. We discuss a number of mouse models with degraded FSL/jitter whose mutations occur exclusively in the central auditory system and therefore might serve as candidates to investigate the cellular mechanisms underlying auditory processing disorders (APD).

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