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Hippocampal spike-timing correlations lead to hexagonal grid fields

Phys Rev Lett 119, 038101 - Published 19 July 2017.

Authors/Editors: Monsalve-Mercado MM
Leibold C
Publication Date: 2017
Type of Publication: Journal Articles 2001 - 2017

Abstract

Space is represented in the mammalian brain by the activity of hippocampal place cells, as well as in their spike-timing correlations. Here, we propose a theory for how this temporal code is transformed to spatial firing rate patterns via spike-timing-dependent synaptic plasticity. The resulting dynamics of synaptic weights resembles well-known pattern formation models in which a lateral inhibition mechanism gives rise to a Turing instability. We identify parameter regimes in which hexagonal firing patterns develop as they have been found in medial entorhinal cortex.

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