The goal of the Keays lab is to answer important questions in sensory and developmental neuroscience. We do this by relying on creative experimental design, that is complemented by a reductionist mindset that pays unrelenting attention to detail.
We are focused on three questions:
In tackling these questions we adopt a inter-disciplinary approach, employing a broad range of genetic, molecular, cellular, and behavioural tools. Click on the links above to find out more about these projects.
- 2-photon Imaging
- iDISCO whole brain imaging
- RNA and exome sequencing
- iPSC and ES culture
- CRISPR/CAS9 genome editing
- Cerebral Organoid Generation
- Transgenic Mouse Technology
- Mass spectroscopy
- Molecular and biochemical assays.
- ERC Consolidator Grant
Hochstoeger et al. The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor. Sci Adv. 2020 Aug 12;6(33).
Nimpf S, et al. A putative mechanism for magnetoreception by electromagnetic induction in the pigeon inner ear. Curr Biol. 2019 Dec 2;29(23):4052-4059
Tripathy, et al. Mutations in MAST1 cause mega corpus callosum syndrome and cortical malformations. Neuron. 2018 Dec 19;100(6):1354-1368.
Gstrein et al. Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans. Nature Neuroscience. (2018) Feb;21(2):207-217.
Breuss M, et al. Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis. Development. 2016 Apr 1;143(7):1126-33
Edelman, NB., et al. (2015). No evidence for intracellular magnetite in putative vertebrate magnetoreceptors identified by magnetic screening. PNAS. 112(1):262-7
Treiber, CD., et al. (2012). Clusters of iron-rich cells in the upper beak of pigeons are macrophages not magnetosensitive neurons. Nature. 484(7394):367-70.
Keays et al, Mutations in α-tubulin cause defects in neuronal migration in mice and lissencephaly in humans. Cell. 2007 Jan 12;128(1):45-57.